Mammalian Anatomy

Mammalian Anatomy

Anatomy of Mammalian Replication Domains

Genetic information is faithfully copied by DNA replication through many rounds of cell division. In mammals, DNA is replicated in Mb-sized chromosomal units called "replication domains." While genome-wide maps in multiple cell types and disease states have uncovered both dynamic and static properties of replication domains, we are still in the process of understanding the mechanisms that give ...

Functional anatomy of distant-acting mammalian enhancers.

Transcriptional enhancers are a major class of functional element embedded in the vast non-coding portion of the human genome. Acting over large genomic distances, enhancers play critical roles in the tissue and cell type-specific regulation of genes, and there is mounting evidence that they contribute to the aetiology of many human diseases. Methods for genome-wide mapping of enhancer regions ...

Introduction to the functional anatomy of the mammalian motor unit.

The main function of skeletal muscles is production of force in a controlled manner. Force is generated by highly specialized cells, the muscle fibres, by the interaction between their two main constituents, i.e. myosin and actin. In mammalian skeletal muscle fibres the actin and myosin molecules are neatly aligned to form sarcomeres. Several such units are connected along the longitudinal axis...

Mammalian distal tubule: physiology, pathophysiology, and molecular anatomy.

The distal tubule of the mammalian kidney, defined as the region between the macula densa and the collecting duct, is morphologically and functionally heterogeneous. This heterogeneity has stymied attempts to define functional properties of individual cell types and has led to controversy concerning mechanisms and regulation of ion transport. Recently, molecular techniques have been used to ide...